Sphingolipids and Metabolic Disease

Sphingolipids and Metabolic Disease

Sphingolipids and Metabolic Disease by L. Ashley Cowart

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Author: L. Ashley Cowart
Number of Pages: 166 pages
Published Date: 05 Aug 2011
Publisher: Springer-Verlag New York Inc.
Publication Country: New York, NY, United States
Language: English
ISBN: 9781461406495
File Name: Sphingolipids.and.Metabolic.Disease.pdf
Download Link: Sphingolipids and Metabolic Disease
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Current thinking holds that obesity derives primarily from overnutrition (though compelling arguments for other mechanisms, like endocrine disruption by environmental pollutants, also gain support from the literature). In animals, overnutrition is initially handled by adipose tissue expansion; however, exhaustion of this route of lipid sequestering results in oversupply of lipid to other tissues including skeletal muscle, heart, liver, and others. Failure of these tissues to clear excess lipids through either metabolism or sequestration into putatively inert triacylglycerols results in perturbation of bioactive lipid metabolism in cells. In particular, aberrant generation of bioactive sphingolipids is implicated in a multitude of pathological outcomes of metabolic disease including insulin resistance, inflammation, cardiomyopathy, and others. This volume addresses not only the fundamentals of sphingolipid metabolism and analysis, but also the roles of sphingolipids in these disease processes.

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